Research
Grants Jointly Sponsored by the
CCNNPDF and the NNPDF
The Canadian Chapter of the National Niemann-Pick Disease Foundation (CCNNPDF) is a sister chapter to the National Niemann-Pick Disease Foundation (NNPDF) (U.S.) and receives administrative support from the NNPDF. Money raised through the CCNNPDF is invested in Niemann-Pick Disease research through the NNPDF's research program with guidance from the NNPDF's Scientific Advisory Board (SAB), Board of Directors, and Research Committee. This partnership helps eliminate redundancy and maximizes the impact of research dollars. (Tammy Vaughan, chair of the CCNNPDF, serves as secretary of the NNPDF, and is on the NNPDF's Research Committee.)
Note: The project status shown below reflects only the Foundation's involvement. A number of the studies listed have been continued or expanded under the sponsorship of NIH and other organizations.
(To see a listing of the Fellowships jointly sponsored by the CCNNPDF and NNPDF, click here .)
(To see a listing of the Clinical Research and Services funded by the NNPDF, click here .)
| Item # | Date | Researcher | Project | Additional Information |
| 51 |
10/2013
|
Charles Vite, D.V.M., Ph.D. School of Veterinary Medicine University of Pennsylvania - Philadelphia |
NPC Cat colony "Fellowships of the Cats II"
In Progress |
2013 Family Conference Presentation
2013 Family Conference Presentation
|
| 50 |
08/2011
- 09/2013 |
Charles Vite, D.V.M., Ph.D. School of Veterinary Medicine University of Pennsylvania - Philadelphia |
NPC Cat colony "Fellowships of the Cats I"
Completed |
|
| 49 | 8/2009 | Jackson Laboratory Repository |
Processing the NPD mouse model developed by Dr. Richard Pagano of the Mayo Clinic College of Medicine
$2500 Jointly sponsored by CCNNPDF & NNPDF Completed |
|
| 48 | 4/1/2008 - 3/31/2009 |
Edward H. Schuchman, PhD (Mount Sinai School of Medicine, New York,NY, USA) (1 Year) |
Construction & Characterization of New Mouse Models for Types A & B Niemann-Pick
$46,593 Jointly sponsored by CCNNPDF & NNPDF Completed |
|
| 47 | 3/1/2008 - 2/28/2010 |
Frances M. Platt & Emyr Lloyd-Evans (University of Oxford, Oxford, UK) (2 years) |
Targeting sphingosine storage as a new therapeutic approach for Niemann-Pick type C
$161,097 Jointly sponsored by CCNNPDF & NNPDF Completed |
|
| 46 | 4/1/2007 - 3/31/2008 |
Lysosomal Storage Disease Research Consortium (Multiple)
(1 year) |
Additional contribution to Lysosomal Storage Disease
(LSD) Research Consortium for research into issues of common interest
to all LSD support groups
(See also Grant # 40) $10,000 Jointly sponsored by CCNNPDF & NNPDF Completed |
More Details... |
| 45 | 3/1/2007 - 2/29/2008 |
Frances M. Platt (University of Oxford) (1 year) |
Evaluation of anti-inflammatory intervention (NSAIDS)
as an adjunctive therapy in Niemann-Pick Type C1 disease.
$99,090 Jointly sponsored by CCNNPDF & NNPDF Completed |
|
| 44 | 4/1/2006 - 3/31/2007 |
Lysosomal Storage Disease Research Consortium (Multiple)
(1 year) |
Additional contribution to LSD Research Consortium for
research into issues of common interest to all LSD support groups
(See also Grant # 40) $10,000 Completed |
More Details... |
| 43 | 9/1/2006 - 8/31/2007 |
Maria D. Ledesma, Ph.D. (Catholic University of Leuven; Leuven; Belgium) (1 year) |
Analysis of Dendritic Spine Alterations in Niemann-Pick
Disease Type A Neurons
$19,760 Bridge Funding Completed |
More Details... |
| 42 | 6/1/2006 - 12/31/2007 |
Kostantin Dobrenis, Ph.D.
(Albert Einstein College of Medicine of Yeshiva University; Bronx, New York; USA) (18 months) |
Establishment of Central Nervous System Cell Lines from
NPC-1 Disease Mice for Pathogenic and Therapeutic Studies
$80,240 Completed |
More Details... |
| 41 | 5/1/2006 - 11/30/2006 |
Frances M. Platt, Ph.D. (University of Oxford; Oxford, England; UK) (7 months) |
Therapeutic Monitoring of Glycolipid Storage Diseases
in the Clinic Using Cell Biological Assays and Proteomics
$50,000 Bridge Funding Completed |
More Details... |
| 40 | 4/1/2004 - 3/31/2006 | Lysosomal Storage Disease Research Consortium (Multiple) |
Lysosomal Storage Disease Research Consortium Contribution
for NNPDF to Join Consortium
$10,000 Completed |
More Details... |
| 39 | 4/15/2005 - 4/14/2006 |
Robert A. Maue, Ph.D.
(Dartmouth Medical School; Hanover, New Hampshire; USA) (1 year) |
Maintenance of Colony of NPC1 mice with GFP-tagged Purkinje
neurons
$6,000 Bridge Funding Completed |
More Details... |
| 38 | 5/1/2005 - 4/30/2006 |
Thomas J. Kelley, Ph.D.
(Case Western Reserve University; Cleveland, Ohio; USA) (1 year) |
NOS2 regulation in NPC
$55,000 Major funding provided by the Niemann-Pick Disease Group (UK) . Completed |
More Details... |
| 37 | 4/1/2005 - 4/1/2007 |
Richard E. Pagano, Ph.D. and David L. Marks, Ph.D.
(Mayo Clinic and Foundation; Rochester, Minnesota; USA) (2 years) |
Reduction of stored lipids in Niemann-Pick Type C mice
by rab protein expression
$177,562 Completed |
More Details... |
| 36 | 9/15/2004 - 9/14/2005 |
Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Organization of Synapses in Niemann-Pick Disease Type
A
$50,000 Completed |
More Details... |
| 35 | 4/1/2004 - 3/31/2005 |
Synthia Mellon, Ph.D.
(University of California, San Franciso; San Francisco, California, USA) (1 year) |
SSRIs as a potential therapy for NP-C
$50,000 Jointly funded with Dana's Angels Research Trust . Total project cost is: $97,769. Completed |
More Details... |
| 34 | 3/1/2004 - 2/28/2005 |
Stuart A. Lipton, M.D., Ph.D.
(The Burnham Institute; La Jolla, California, USA) (1 year) |
NMDA receptor hypofunction in Niemann-Pick disease Type
A
$50,000 Completed |
More Details... |
| 33 | 9/15/2003 - 9/14/2004 |
Makoto Michikawa, M.D., Ph.D.
(National Institute for Longevity Sciences; Aichi, Japan) (1 year) |
Cellular and Molecular Mechanisms Underlying Neurodegeneration
in Niemann- Pick Type C disease
$50,000 Completed |
More Details... |
| 32 | 7/1/2003 - 8/31/2004 |
Timothy M. Cox, MD, FRCP, FMedSci & Robin Henry
Lachmann, M.A., M.B., Bchir, Ph.D.
(University of Cambridge; Cambridge, United Kingdom) (10 months) |
Therapeutic Gene Delivery to the Cerebellum in Niemann-Pick
Type C
$40,000 (Transitional Funding - used for PostDoc) Completed |
More Details... |
| 31 | 8/15/2002 - 8/14/2003 |
Maria D. Ledesma, Ph.D. (Fundazione Cavalieri Ottolenghi; Turin, Italy) (1 year) |
Niemann-Pick Disease Type A: Molecular Analysis of Neuronal
Membrane Maturation and Synapse Formation
$50,000 Completed |
More Details... |
| 30 | 8/1/2002 - 7/31/2003 |
Anita H. Corbett, Ph.D.
(Emory University School of Medicine; Atlanta, Georgia, USA) (1 year) |
Functional Analysis of NPC1
$50,000 Completed |
More Details... |
| 29 | 2/15/2002 - 2/14/2003 |
Melanie Jean Dobson, Ph.D.
(Dalhousie University; Halifax, Nova Scotia, Canada) (1 year) |
A Yeast System for Analysis of Sterol Trafficking Defects
in NPC
$42,000 Completed |
More Details... |
| 28 | 8/15/2001 - 8/14/2003 |
Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) (2 years) |
The Role of HE1 in Cholesterol Trafficking
$154,147 Completed |
More Details... |
| 27 | 8/15/2001 - 8/14/2002 |
Skadrite Krisans, Ph.D.
(San Diego State University; San Diego, California, USA) (1 year) |
Role of Peroxisomal Cholesterol/Myelin Formation in
the CNS Pathology of the NPC Mouse
$50,000 completed |
|
| 26 | 2/1/2001 - 1/31/2002 |
Anthony H. Futerman, Ph.D.
(Weizmann Institute; Rehovot, Israel) (1 year) |
Neuronal Development & Death in Type A Niemann-Pick
Disease
$50,000 Completed |
More Details... |
| 25 | 8/15/2000 - 8/14/2001 |
Mary Anna Thrall; DMV
(Colorado State University; Fort Collins, Colorado, USA) (1 year) |
Characterization of Feline Niemann-Pick Type C
$40,216 Completed |
|
| 24 | 9/1/2000 - 8/31/2001 |
Yiannis A. Ioannou, Ph.D. (Mount Sinai School of Medicine; New York, New York, USA) (1 year) |
Functional Characterization of NPC1L1, a Human Homologue
of NPC1
$60,000 Completed |
|
| 23 | 8/15/2000 - 8/14/2003 |
Robert A. Maue, Ph.D.
(Dartmouth College) (3 years) |
Analysis of Growth Factor Actions and Membrane Polarity
in Neurons from NP-C Mice
$131,988 (No Cost Extension Received in August, 2002; Completion Date Changed to August, 2003) Completed |
More Details... |
| 22 | April, 2000 |
Daniel S. Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of the Niemann-Pick Type C2 Gene
$125,752 Completed |
|
| 21 | February, 2000 |
Cynthia J. Forehand, Ph.D.
(University of Vermont; Burlington, Vermont, USA) |
Glutamate Receptors and Neuronal Degeneration in Niemann-Pick
Type C Disease
$27,107 completed |
|
| 20 | April, 2000 |
Lisa D. Griffin, M.D., Ph.D.
(University of California - San Francisco; San Francisco, California, USA) |
Altered Neurosteroidogenesis in Niemann-Pick Type C
Disease
$40,000 (Extension of Grant # 16) Completed |
|
| 19 | February, 2000 |
James Shayman, M.D.
(University of Michigan; Ann Arbor, Michigan, USA) |
Treatment of Niemann-Pick Type C Disease with Potent
Inhibitors of Cerebroside Synthase
$40,000 completed |
|
| 18 | August, 1999 |
Leslie P. Henderson
(Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,592 (Extension of Grant # 10) Completed |
|
| 17 | July, 1999 |
Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene
$110,000 Extended (See Grant # 22) |
|
| 16 | June, 1999 |
Lisa Griffin, M.D., Ph.D.
(University of California - San Francisco; San Francisco, California, USA) |
The Role of Neurosteroids in the Development of Niemann-Pick
Type C
$34,000 Completed |
|
| 15 | June, 1999 |
Frederick R. Maxfield, Ph.D.
(Weill Medical College of Cornell University; New York, New York, USA) |
Intracellular Cholesterol Trafficking in Niemann-Pick
Type C Disease
$15,000 Completed |
|
| 14 | September, 1998 |
Jerry Reagan, Ph.D.
(Wake Forest University School of Medicine; Winston-Salem, North Carolina, USA) |
Acid Sphingomyelinase Regulates Cholesterol Egress from
Lysosomes by an Alternative Pathway
$15,000 Completed |
|
| 13 | April, 1998 |
Daniel Ory, M.D. (Washington University School of Medicine; St. Louis, Missouri, USA) |
Molecular Cloning of NPC2 Gene
$60,000 Extended (See Grant #17) |
|
| 12 | February, 1998 |
Jill Morris, Ph.D.
(National Institutes of Health; Bethesda, Maryland, USA) |
Identification of Additional NPC1 Mutations
$31,000 Completed |
|
| 11 | March, 1998 |
Ira Tabas, M.D., Ph.D.
(Columbia University; New York, New York, USA) |
Phospholipid Metabolism and Cholesterol-Induced Cytotoxicity
in Niemann-Pick C Macrophages
$15,000 Completed |
|
| 10 | March, 1998 |
Leslie P. Henderson, Ph.D.
(Dartmouth College, Hanover, New Hampshire, USA) |
Analysis of NPC1 mRNA Expression in the Mouse Brain
$14,742 Extended (See Grant # 18) |
|
| 9 | March, 1997 |
Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA) |
Lipid Trafficking in the Neurons of NPC Mice
$11,000 Completed |
|
| 8 | January, 1997 |
Synthia Mellon, Ph.D.
(University of California - San Francisco; San Francisco, California; USA) |
Potential Involvement of Neurosteroids in the Neurobiological
Dysfunctions of NP-C
$30,044 Completed |
|
| 7 | October, 1996 |
Marc Patterson, M.D. (Mayo Clinic; Rochester, Minnesota, USA) |
Establish an International Registry (database) of NPC
Families
$10,213 |
|
| 6 | July, 1996 |
G. S. Tint, Ph.D.
(Veterans Adminstration Medical Center; East Orange, New Jersey, USA) |
Accumulation of Oxidized Cholesterol as a Possible Cause
of Pathologies Associated with Niemann-Pick Type C Disease
$14,000 Completed |
|
| 5 | June, 1996 |
John R. Sargent, Ph.D.
(University of Stirling; Stirling, Scotland, United Kingdom) |
Influence of Exogenous Fatty Acids on Levels of Cholesterol
in Cultured Skin Fibroblasts from NPC Patients
$28,050 Completed |
|
| 4 | January, 1996 |
Wenda L. Greer, Ph.D.
(Dalhousie University; Halifax, Nova Scotia, Canada) |
Identification of Niemann-Pick Type D Patients with
Arcadian Ancetsry as a Step Toward Isolation of the Defective Gene
$12,357 Completed |
|
| 3 | Nov, 1995 |
Charles C. Schwartz, M.D.
(Medical College of Virginia; Richmond, Virginia, USA) |
Quantitation of Cholesterol Transport and Tissue Cholesterol
Pool Sizes In Vivo Niemann-Pick Type C Disease
$32,000 Completed |
|
| 2 | April, 1994 |
Laura Liscum, Ph.D.
(Tufts University School of Medicine; Boston, Massachusetts, USA) |
Complementation Analyses of Niemann-Pick Type C Fibroblasts'
Cholesterol Transport in Defective CHO Cells
$8,900 Completed |
|
| 1 | 7/1/1993 - 6/30/1997 |
Eugene Carstea, Ph.D.
(National Institutes of Health; Bethesda, Maryland, USA) (5 years) |
Identify the Gene Responsible for Niemann-Pick Type
C Disease
$160,000 Completed |
More Details... |
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